Feske Lab

Mechanisms and function of calcium channels in the immune system

The Feske lab investigates calcium signaling pathways in cells of the immune system. We study the molecular regulation of CRAC channel proteins of the STIM and ORAI families. By analyzing transgenic animal models and human patients with inherited immunodeficiency we investigate the role of CRAC channels for immune responses to infection and in autoimmunity.

Research Keywords: CRAC channel, calcium, store-operated calcium entry, ORAI1, STIM1, immunodeficiency

Postdoctoral Positions

Postdoctoral positions in immunology and signal transduction available in the Feske Lab Read more

Publications from the Feske Lab

Patients with mutations in ORAI1 and STIM1 define novel immunodeficiency syndrome Read more

Publications from the Feske Lab

CRAC channel function mediated by ORAI and STIM proteins is required for proinflammatory effector T cell function in autoimmunity Read more